The anti-phospholipid syndrome (APS) is a systemic autoimmune disease characterized by the occurrence of arterial and venous thrombosis and/or obstetric complications (miscarriage, fetal death in utero) associated with the presence of anti-phospho-

The anti-phospholipid syndrome (APS) is a systemic autoimmune disease characterized by the occurrence of arterial and venous thrombosis and/or obstetric complications (miscarriage, fetal death in utero) associated with the presence of anti-phospholipid antibodies (1). The catastrophic anti-phospholipid syndrome (CAPS) is its most severe manifestation, and is characterized by the occurrence of thrombosis in multiple organs over a short period of time (2). CAPS is rare, affecting less than 1% of patients with APS. We here report two cases of patients admitted to our intensive care unit (ICU) for multi-organ failure related to CAPS, and who were treated successfully. Their management is discussed at the light of existing literature.